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Page 1
Antagonistic Effect and In Vitro Activity of Dauricine on Glucagon Receptor.
Li L, Dai S, Liu JY, Wu W, Zhao QX, Wang X, Wang N, Xu ZH. Li L, et al. J Nat Prod. 2022 Aug 26;85(8):2035-2043. doi: 10.1021/acs.jnatprod.2c00446. Epub 2022 Jul 14. J Nat Prod. 2022. PMID: 35834753 Review.
Dauricine, the lead compound of glucagon receptor antagonist (GRA), was screened using the GRA screening model in vitro. Finally, using [Des-His1, Glu9]-Glucagon amide as the positive control, flow cytometry was used to express the antagonistic effect of the compound. Cons …
Dauricine, the lead compound of glucagon receptor antagonist (GRA), was screened using the GRA screening model in vitro. Finally, usi …
Dauricine attenuates ovariectomized-induced bone loss and RANKL-induced osteoclastogenesis via inhibiting ROS-mediated NF-kappaB and NFATc1 activity.
Lin X, Yuan G, Yang B, Xie C, Zhou Z, Liu Y, Liu Z, Wu Z, Akimoto Y, Li N, Xu R, Song F. Lin X, et al. Phytomedicine. 2024 Mar 20;129:155559. doi: 10.1016/j.phymed.2024.155559. Online ahead of print. Phytomedicine. 2024. PMID: 38579642
PURPOSE: We aim to search for natural compound that may suppress osteoclast formation and function. STUDY DESIGN: In this study, we assessed the impact of Dauricine (Dau) on the formation and function of osteoclasts in vitro, as well as its potential in preventing bone los …
PURPOSE: We aim to search for natural compound that may suppress osteoclast formation and function. STUDY DESIGN: In this study, we assessed …
Antioxidative and antiapoptosis: Neuroprotective effects of dauricine in Alzheimer's disease models.
Wang L, Pu Z, Li M, Wang K, Deng L, Chen W. Wang L, et al. Life Sci. 2020 Feb 15;243:117237. doi: 10.1016/j.lfs.2019.117237. Epub 2019 Dec 27. Life Sci. 2020. PMID: 31887302
KEY FINDINGS: In vitro, dauricine decreased the secretion level of Abeta(1)(-)(42), significantly reduced the level of Cu(2+)-induced ROS, and restored MMP and SOD activity in APPsw cells. ...SIGNIFICANCE: Those data revealed that dauricine has the pharmacolo …
KEY FINDINGS: In vitro, dauricine decreased the secretion level of Abeta(1)(-)(42), significantly reduced the level of Cu(2+)-induced …
Dauricine negatively regulates lipopolysaccharide- or cecal ligation and puncture-induced inflammatory response via NF-kappaB inactivation.
Qiao B, Wang H, Wang C, Liang M, Huang K, Li Y. Qiao B, et al. Arch Biochem Biophys. 2019 May 15;666:99-106. doi: 10.1016/j.abb.2019.03.018. Epub 2019 Apr 1. Arch Biochem Biophys. 2019. PMID: 30946805
Moreover, dauricine could suppress LPS-mediated nuclear translocation and transcriptional activity of nuclear factor-kappaB (NF-kappaB) by suppressing the phosphorylation of NF-kappaB inhibitors (IkappaB). ...Collectively, the present study discovers a new biologica …
Moreover, dauricine could suppress LPS-mediated nuclear translocation and transcriptional activity of nuclear factor-kappaB (N …
Herbal Compounds Dauricine and Isoliensinine Impede SARS-CoV-2 Viral Entry.
Dabrell SN, Li YC, Yamaguchi H, Chen HF, Hung MC. Dabrell SN, et al. Biomedicines. 2023 Oct 27;11(11):2914. doi: 10.3390/biomedicines11112914. Biomedicines. 2023. PMID: 38001915 Free PMC article.
Since ACE2 and TMPRSS2 are conveniently located on the surface of host cells, targeting one or both receptors may inhibit receptor-ligand interaction. Here, we show that Dauricine and Isoliensinine, two commonly used herbal compounds, were capable of inhibiting SARS-CoV-2 …
Since ACE2 and TMPRSS2 are conveniently located on the surface of host cells, targeting one or both receptors may inhibit receptor-ligand in …
Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity.
Wu MY, Wang SF, Cai CZ, Tan JQ, Li M, Lu JJ, Chen XP, Wang YT, Zheng W, Lu JH. Wu MY, et al. Oncotarget. 2017 Sep 8;8(44):77673-77684. doi: 10.18632/oncotarget.20767. eCollection 2017 Sep 29. Oncotarget. 2017. PMID: 29100416 Free PMC article.
Inhibition of autophagy has been regarded as a new therapeutic strategy for cancer treatment, especially in combination with chemotherapy. In our study, we identified two natural compounds, dauricine (DAC) and daurisoline (DAS), as two potent autophagy blockers through a h …
Inhibition of autophagy has been regarded as a new therapeutic strategy for cancer treatment, especially in combination with chemotherapy. I …
Pulmonary toxicity and metabolic activation of dauricine in CD-1 mice.
Jin H, Dai J, Chen X, Liu J, Zhong D, Gu Y, Zheng J. Jin H, et al. J Pharmacol Exp Ther. 2010 Mar;332(3):738-46. doi: 10.1124/jpet.109.162297. Epub 2009 Dec 11. J Pharmacol Exp Ther. 2010. PMID: 20008063
The objective of the current study was to evaluate the toxicity of dauricine in vitro and in vivo. Mice (CD-1) were treated intraperitoneally with dauricine at various doses, and sera and lung lavage fluids were collected after 24 h of treatment. ...In conclusion, …
The objective of the current study was to evaluate the toxicity of dauricine in vitro and in vivo. Mice (CD-1) were treated intraperi …
Dauricine combined with clindamycin inhibits severe pneumonia co-infected by influenza virus H5N1 and Streptococcus pneumoniae in vitro and in vivo through NF-kappaB signaling pathway.
Li H, Chen X, Zhou SJ. Li H, et al. J Pharmacol Sci. 2018 May;137(1):12-19. doi: 10.1016/j.jphs.2018.01.011. Epub 2018 Apr 19. J Pharmacol Sci. 2018. PMID: 29769163 Free article.
However, little is known regarding to the effect of dauricine on severe pneumonia. Therefore, the aim was to investigate the effect of dauricine on severe pneumonia and its mechanism during progress. ...In vivo, dauricine significantly decreased MPO activi …
However, little is known regarding to the effect of dauricine on severe pneumonia. Therefore, the aim was to investigate the effect o …
Bisbenzylisoquinoline alkaloids and P-glycoprotein function: A structure activity relationship study.
Xu W, Chen S, Wang X, Wu H, Yamada H, Hirano T. Xu W, et al. Bioorg Med Chem. 2020 Jun 15;28(12):115553. doi: 10.1016/j.bmc.2020.115553. Epub 2020 May 11. Bioorg Med Chem. 2020. PMID: 32503690
Several kinds of bisbenzylisoqunoline alkaloids were reported to modulate P-glycoprotein function and reverse drug resistance. In order to provide more information for their structure activity relationship on P-glycoprotein function, the effects of tetrandrine, isotetrandr …
Several kinds of bisbenzylisoqunoline alkaloids were reported to modulate P-glycoprotein function and reverse drug resistance. In order to p …
Dauricine regulates prostate cancer progression by inhibiting PI3K/AKT-dependent M2 polarization of macrophages.
Li M, Che N, Liu X, Xuan Y, Jin Y. Li M, et al. Biochem Pharmacol. 2023 Nov;217:115838. doi: 10.1016/j.bcp.2023.115838. Epub 2023 Sep 29. Biochem Pharmacol. 2023. PMID: 37778445
M2 type tumor-associated macrophages, an essential component of the tumor microenvironment (TME), have been proved to contribute to tumor metastasis. Dauricine (Dau) has recently received widespread attention due to its multiple targets and low price. ...Our results showed …
M2 type tumor-associated macrophages, an essential component of the tumor microenvironment (TME), have been proved to contribute to tumor me …
39 results